Cisplatin lysosomes
WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … WebOct 1, 2024 · Cisplatin, sequestered in the lysosome is freed by the LMP action of CPTNPs, allowing for increased availability of cisplatin and increased cell death. (For …
Cisplatin lysosomes
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WebJan 1, 2016 · Ctr1 imports platinum-based drugs into the cell. The drug enters the nucleus, induces DNA crosslinking, resulting in DNA damage, cell cycle arrest and apoptosis (a). … WebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to control lysosomal...
WebOct 1, 2024 · The Lysosomal pH shift induces nanofibril formation and lysosomal membrane permeation, thereby releasing the lysosomal contents into the cytoplasm and inducing LMP mediated cell death and cisplatin sensitization. Figure … WebOct 13, 2024 · Cisplatin is an inorganic platinum derivative that is widely used for chemotherapy of various solid tumours. In cancer cells, cisplatin induces DNA crosslinks and DNA adducts, triggering the...
WebBafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy. Author links open overlay panel Hong-Ying Chu a b 1, Wei Wang a 1, Xue Chen a, ... Lysosome is a potential target for increasing the cytotoxicity of DDP. WebMay 10, 2024 · This HIF/Ferritin axis is responsible for etoposide- and cisplatin-induced iron reduction in lysosomes and stemness of SCLC cells. This work demonstrates that …
WebLysosomes have been proposed to sequester drugs, including cisplatin, and may therefore contribute to drug resistance. However, the mechanism(s) that facilitate this remains unclear. Our work demonstrates that the CACC TMEM16A drives lysosomal … We would like to show you a description here but the site won’t allow us.
WebLysosome-associated membrane protein (LAMP)-1, one of the major protein components of the lysosomal membrane, is upregulated in the human glioblastoma cell lines, U-373 MG and LN-Z308, which undergo cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to … shrewsbury hotel wetherspoons menuWebLysosome Fe 2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells Iron metabolism has been shown to hand over cancer stem cell, which is regarded as the root of tumor progression, recurrence and chemoresistance. shrewsbury house school sports groundWebOct 28, 2024 · Annexin A2 (ANXA2) is a phospholipid-binding protein involving in organelle membrane integrity function, suggesting its important role in autophagy and lysosome homeostasis. It implicates ANXA2... shrewsbury house community centre greenwichWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … shrewsbury hotels near train stationWebApr 15, 2003 · Cisplatin (CP) is a component of standard treatment regimens for testicular, ovarian, bladder, cervical, head and neck and small-cell and nonsmall-cell lung cancers (Ozols and Williams, 1989 ... shrewsbury house school surbitonWebApr 26, 2016 · Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity. Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. shrewsbury house schoolWebFeb 1, 2014 · Here we show that a synergistic interaction can be achieved between sunitinib and cisplatin through a mechanism involving both the apoptotic and the autophagic/lysosomal systems. Such drug cooperation results in enhanced growth inhibition and cell death in both MTC cell culture and tumor xenografts. Materials and Methods … shrewsbury hotel wetherspoons