WebDec 2, 2024 · We describe the preclinical development of BT8009, a "Bicycle Toxin Conjugate" (BTC) consisting of a Nectin-4-binding bicyclic peptide, a cleavable linker … WebSep 10, 2024 · BT8009 is a second-generation BTC, which uses a valine-citrulline cleavable linker and a cytotoxin MMAE payload. It targets Nectin-4, which is a well-validated tumor …
BT8009-100 Phase I/II Study of Novel Bicyclic Peptide and …
WebNov 3, 2024 · Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC®) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle TICA® targeting Nectin-4 and agonizing CD137, in company-sponsored Phase I/II trials. WebMar 8, 2024 · Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC™) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480,... buddbox cell phone covers
Bicycle Therapeutics to Present at the 2024 AACR Annual Meeting ...
Web3 hours ago · Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC™) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480 ... WebApr 7, 2024 · BT8009, a Nectin-4 targeting BTC with a potentially differentiated profile to marketed ADC Phase I/II Trial of BT8009 Currently On Track to Initiate in 2024. In preclinical studies, BT8009... WebDec 1, 2024 · BT8009 has low nanomolar (3nM) affinity for Nectin-4 and high selectivity (>1000 fold) over Nectins 1-3 and the 5 nectin-like family members (Necl1-5). BT8009 is active in a broad range of Nectin-4 positive cell line and patient derived xenograft tumors in vivo, leading to stable diseases and tumor regressions with durable responses. budd broadcasting